NPS

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Events

Second training Neptune: Guidance on the Management of Acute and Chronic Harms of Club Drugs and New Psychoactive Substances

The EU4Monitoring Drugs (EU4MD) project of the EMCDDA is co-organising the Second training Neptune: Guidance on the Management of Acute and Chronic Harms of Club Drugs and New Psychoactive Substances...

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DARK classics in chemical neuroscience: etonitazene and related benzimidazoles

cover report 4F-MDMB-BICA

Risk assessment report on a new psychoactive substance: methyl 2-{[1-(4-fluorobutyl)-1H-indole-3-carbonyl]amino}-3,3-dime- thylbutanoate (4F-MDMB-BICA) in accordance with Article 5c of Regulation (EC) No 1920/2006 (as amended)

This risk assessment report presents the summary findings and the conclusion of the risk assessment carried out by the Scientific Committee of the EMCDDA on 4F-MDMB-BICA. The report is intended for policymakers and decision-makers in the institutions of the EU. Explanatory note: In the interests...

cover risk assessment MDMB-4en-PINACA

Risk Assessment Report on a new psychoactive substance: methyl 3,3-dimethyl-2-{[1-(pent-4-en-1-yl)-1H-indazole-3-car- bonyl]amino}butanoate (MDMB-4en-PINACA) in accordance with Article 5c of Regulation (EC) No 1920/2006 (as amended)

This risk assessment report presents the summary findings and the conclusion of the risk assessment carried out by the Scientific Committee of the EMCDDA on MDMB-4en- PINACA. The report is intended for policymakers and decision-makers in the institutions of the EU. Explanatory note: In the...

hand holding tube in laboratory

European Commission proposes to control two harmful new psychoactive substances

Today, the European Commission has proposed to control two harmful new psychoactive substances (NPS) across the European Union. The substances in question — MDMB-4en-PINACA and 4F-MDMB-BICA — are both synthetic cannabinoids, which have been raising health concerns in Europe (1). The proposal to...

Cover page of risk assessment guidelines

EMCDDA operating guidelines for the risk assessment of new psychoactive substances

The purpose of these guidelines is to ensure compliance with the scope and requirements of Regulation (EC) No 1920/2006 (as amended) and Council Framework Decision 2004/757/JHA (as amended) in respect to the risk assessment procedure for and reporting on new psychoactive substances. To...

EMCDDA technical report on the new psychoactive substance methyl 3,3-dimethyl-2-{[1-(pent-4-en-1-yl)-1H-indazole-3-carbonyl]amino}butanoate (MDMB-4en-PINACA)

The purpose of this technical report is to provide an analysis of the available information on methyl 3,3-dimethyl-2-{[1-(pent-4-en-1-yl)-1H-indazole-3-carbonyl]amino}butanoate (commonly known as MDMB-4en-PINACA), a synthetic cannabinoid receptor agonist that has recently emerged on the drug market...

EMCDDA technical report on the new psychoactive substance methyl 2-{[1-(4-fluorobutyl)-1H-indole-3-carbonyl]amino}-3,3-dimethylbutanoate (4F-MDMB-BICA)

The purpose of this technical report is to provide an analysis of the available information on methyl 2-{[1-(4-fluorobutyl)-1H-indole-3-carbonyl]amino}-3,3-dimethylbutanoate (commonly known as 4F-MDMB-BICA), a synthetic receptor cannabinoid agonist that has recently emerged on the drug market in...

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New psychoactive substances: global markets, glocal threats and the COVID-19 pandemic — an update from the EU Early Warning System

In this update from the the EU Early Warning System aims to provide insights into what is happening with new psychoactive substances in Europe, based on data from the agency’s early warning and risk-assessment activities. The report covers the period until October 2020 and this year focuses on...

Events

Meeting on the risk assessment of the new psychoactive substances 4F-MDMB-BICA and MDMB-4EN-PINACA

The extended Scientific Committee of the EMCDDA meets on 7 December 2020 to examine the risk assessment by the EMCDDA on 4F-MDMB-BICA and MDMB-4EN-PINACA.

VII International Conference on Novel Psychoactive Substances (NPS)

The VII International Conference on Novel Psychoactive Substances (NPS) is jointly organised by the International Society for the Study of Emerging Drugs (ISSED), the United Nations Office on Drugs...

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Commission Delegated Directive on isotonitazene

Isotonitazene is a synthetic opioid analgesic and is closely related to etonitazene and clonitazene, both of which are under international control under the 1961 United Nations Single Convention on...

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Report on the risk assessment of N,N-diethyl-2- [[4-(1-methylethoxy)phenyl]methyl]-5-nitro-1Hbenzimidazole- 1-ethanamine (isotonitazene) in accordance with Article 5c of Regulation (EC) No 1920/2006 (as amended)

This publication presents the data and findings of the risk assessment on N,N-diethyl-2-[[4-(1-methylethoxy)phenyl]methyl]-5-nitro-1H-benzimidazole-1- ethanamine (isotonitazene), carried out by the extended Scientific Committee of the EMCDDA on 26 May 2020. On the basis of the Risk Assessment...

EMCDDA initial report on the new psychoactive substance MDMB-4en-PINACA

Methyl 3,3-dimethyl-2-(1-(pent-4-en-1-yl)-1H-indazole-3-carboxamido)butanoate (MDMB-4en-PINACA) is a synthetic cannabinoid receptor agonist. Similar to other synthetic cannabinoids, it is sold as a ‘legal’ replacement for cannabis and controlled synthetic cannabinoids. Because of their high potency...

EMCDDA initial report on the new psychoactive substance 4F-MDMB-BICA

Methyl 2-({[1-(4-fluorobutyl)-1H-indol-3-yl]carbonyl}amino)-3,3-dimethylbutanoate (4F-MDMB-BICA) is a synthetic cannabinoid receptor agonist. Similar to other synthetic cannabinoids, it is sold as a ‘legal’ replacement for cannabis. Because of their high potency, synthetic cannabinoids can pose a...

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EMCDDA technical report on the new psychoactive substance N,Ndiethyl- 2-[[4-(1-methylethoxy)phenyl]methyl]-5-nitro-1Hbenzimidazole- 1-ethanamine (isotonitazene)

The purpose of this technical report is to provide an analysis of the available information on N,N-diethyl-2-[[4-(1-methylethoxy)phenyl]methyl]-5-nitro-1H-benzimidazole-1-ethanamine (commonly known as isotonitazene), an opioid analgesic that has recently emerged on the drug market in Europe, to...

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Document library: COPOLAD early warning systems (EWS) on NPS and emerging drug phenomena

This manual was developed with the goal of promoting and facilitating the establishment of Early Warning Systems (EWSs) and agreements for information exchange between National Drug Councils,...

Events

Meeting on the risk assessment of the new psychoactive substance isotonitazene

The extended Scientific Committee of the EMCDDA meets on 26 May 2020 to examine the risk assessment by the EMCDDA on isotonitazene.

EMCDDA initial report on the new psychoactive substance N,N-diethyl-2-[[4-(1-methylethoxy)phenyl]methyl]-5-nitro-1H-benzimidazole-1-ethanamine (isotonitazene)

Isotonitazene is a synthetic opioid analgesic monitored by the EMCDDA as a new psychoactive substance through the European Union Early Warning System since 2019. Based on potential public health risks, an initial report has been prepared and submitted to the Commission and the Member States, in...

Publication cover_EWS guidelines

EMCDDA operating guidelines for the European Union Early Warning System on new psychoactive substances

These guidelines provide the rationale, steps, procedures, roles, and responsibilities for the operation of the EU Early Warning System. They reflect the requirements of Regulation (EC) No 1920/2006 (as amended) and Council Framework Decision 2004/757/JHA (as amended) with respect to information...

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