As a result of the national measures that have been implemented to contain and mitigate the pandemic of the COVID-19 across Luxembourg, drug services are facing unprecedented challenges to continue providing adequate care to people who use drugs in the community and in prisons. The Luxembourg Focal Point of the EMCCDA (PFLDT) invited the national treatment and harm reduction service providers to participate in a study to rapidly map the impact of COVID-19 lockdown measures on people who use drugs, their drug use patterns and behaviours, and drug services to get better insight in the challenges they face and the responses they introduced accordingly. The PFLDT compiled the responses of each service as part of a larger EMCDDA Trendspotter study assessing the impact in each EU member state. The present report is based on information provided by service providers in the context of the study conducted in Luxembourg between April 7-20 2020. The information is based on individual views and perceptions and do not necessarily represent the views of the entire institutions.