Take-home naloxone (THN) to improve knowledge and attitude towards opioid overdose

Summary of the evidence

  • Beneficial

 Education and naloxone distribution was found in an umbrella review of systematic reviews (Razaghizad et al., 2021, 6 SR containing 87 unique studies) effective in:

  • producing long-term knowledge improvement regarding opioid overdose,
  • improving participants' attitudes toward naloxone
  • providing sufficient training for participants to safely manage overdoses.


Note: this evidence summary is only valid for the outcomes, target groups, settings and substances/patterns of use described below.