Substitution agonist treatments for opiate dependent pregnant women over assisted withdrawal

Summary of the evidence

  • Beneficial

Evidence-based international guidelines (WHO, 2014) strongly recommend to advise opioid dependent pregnant women to use substitution treatment rather than attempt opioid detoxification.

Evidence does not support detoxification as a recommended treatment intervention as a result of low detoxification completion rates, high rates of relapse, and limited data regarding the effect of detoxification on maternal and neonatal outcomes beyond delivery (Dashe et al, 2018).