Injection of synthetic cathinones


Over 80 synthetic cathinone derivatives were detected via the EU Early Warning System (EU–EWS) between 2005 and 2014. This analysis explores new worrying localised and national outbreaks of injecting these substances and recommends close monitoring of the issue as a public health priority.

Part of the ‘Perspectives on drugs’ (PODs) series, launched alongside the annual European Drug Report, these designed-for-the-web interactive analyses aim to provide deeper insights into a selection of important issues.

Update date :

Thursday, June 4, 2015

1. Analysis: injection of synthetic cathinones

hands up in party

Against a backdrop of an overall decline in the injecting of illicit drugs in Europe, recent reports of the injection of new psychoactive substances (NPS), in particular synthetic cathinones, have emerged as a worrying new trend.

Synthetic cathinones first appeared on the European illicit drug market in 2005.These substances have effects similar to known stimulant drugs and are structurally related to cathinone, which is found in the Khat plant (Catha edulis). Mephedrone is the synthetic cathinone that has received particular attention, first appearing as a so-called ‘legal high’ on the market in many countries, before European-level control measures were introduced in 2010. A number of other synthetic cathinones (including pentedrone, methylone, MDPV, 4-MEC and N-ethylbuphedrone) are available and used on the European drug scene. Many synthetic cathinones have, for varying periods of time, been legally available in European countries, often sold through physical retail outlets or via websites. Ease of availability coupled with relatively low prices and high purity compared to street drugs, and popularisation via Internet-driven social media, are likely to have contributed to current levels of use.

Developing a clear understanding of patterns and levels of use of synthetic cathinones in Europe remains a challenge. As it is a relatively new phenomenon, existing monitoring systems are not geared towards it, no agreed analytic laboratory standards exist, and users are seldom aware of precisely which substance or combination of substances they have used. Furthermore purchasing on the Internet enables users to remain discreet and thus a much hidden population. Important insights have been collected for this analysis, however, from a limited number of national and targeted surveys, data presented in Reitox national reports and the scientific literature.

Available evidence suggests that in most countries the use of synthetic cathinones in the general population remains low, and the limited number of countries that have included either mephedrone or other synthetic cathinones in recent general population surveys (1) indicate a last year prevalence rate of 1% or less among adults. However, there are other groups where higher prevalence levels of synthetic cathinone use are reported, such as clubbers, high-risk drug users and treatment entrants. For example, targeted studies of mephedrone use among samples of young European clubbers report last-year prevalence levels of between 1% and 14% (2). In addition, Public Health England (2013) reported the number of clients aged 18 years or over entering treatment for mephedrone use increased between 2011/12 and 2012/13 from 900 to 1630.

While most cathinone use involves either snorting the drugs as a powder or oral use, a recent worrying phenomenon has emerged of synthetic cathinones being injected by some groups of drug users. On the whole, reports suggest that injecting cathinone users are primarily injectors of other drugs (heroin, amphetamines) who, for a variety of reasons, switch to cathinone injection or include cathinones in their drug-using repertoire. In addition, there are reports of long-term abstinent ex-opiate users who have started to inject cathinones (Rácz et al., 2014; Daly, 2012; Van Hout and Bingham, 2012), and limited reports of young people beginning their injecting career with cathinones (Daly, 2012; Austrian Reitox national focal point, 2013).

In some European countries, the injection of synthetic cathinones is reported to be a relatively low-level and localised phenomenon, restricted to particular groups of high-risk drug users (Austria, Belgium, the Czech Republic, France, Germany, Ireland, Poland, Spain and the United Kingdom). In Hungary and Romania, however, a more substantial level of use of synthetic cathinones injection has been identified among large cohorts of high-risk drug users.

Synthetic cathinone injection: two countries with widespread use among high-risk users

In both Hungary and Romania, acute shortages in the availability of heroin in 2010 and 2011, along with the increased availability of cathinones sold as ‘legal highs’ in physical retail outlets in Romania and in online shops in Hungary, have played a role in the development of a generalised level of synthetic cathinones injection among existing cohorts of high-risk drug users. In Hungary, the use of synthetic cathinones mainly among heroin injectors has been documented by needle and syringe programmes, which reported that by 2013 some 58% of programme clients nationwide were injecting cathinones as their primary drug (Hungarian national focal point, 2014). After almost pushing heroin out of the market, synthetic cathinones also began to displace amphetamines. It is interesting to note that the cathinone of choice changed over time in a way that appears to be directly linked with availability — when one cathinone was controlled, it was quickly replaced by a cathinone that was not controlled (see figure).

Hungarian opioid substitution programmes also reported in 2012 that between 10–50% of their clients were using synthetic cathinones. The proportion of primary synthetic cathinone users entering specialised drug treatment for the first time, although not systematically monitored in Hungary, has been estimated at just under 20% in 2012 (Péterfi et al., 2014) with a slight rise observed in 2013 (Hungarian national focal point, 2014).

Analysis of seized injecting equipment (needle, syringe, filter, spoon) in Hungary (3).

graph showing breakdown of synthetic cathinones injected

Source: Hungarian national focal point, 2014

Romania has also recorded a rapid spread in availability and use of synthetic cathinones and other new psychoactive substances, originally made widely available through physical retail outlets (known as ‘dream shops’). A needle and syringe programme in Bucharest, for example, reported in 2012 that of 1 326 surveyed clients, 51% injected new psychoactive substances (mainly synthetic cathinones), 44% injected heroin and 5% injected both NPS and heroin. Data on clients entering specialised drug treatment in Romania in 2012 showed that a third (33%) of clients reported new psychoactive substances as their primary drug. However, 2013 has seen a drop in the number injecting cathinones, with only 18% of clients being NPS users entering treatment. Other indicators (e.g. emergency room admissions, drug related deaths) seem to confirm this decrease.

More limited or localised reports of synthetic cathinones injection

More localised outbreaks of cathinones injection have been identified in several countries, typically involving high-risk drug users in contact with low-threshold facilities, psychiatric facilities, and drug treatment centres.

In France, a recent study has developed a scientific approach to obtain information through the chemical analysis of residues in syringes (Néfau et al., 2015). In total, 3 489 syringes were collected from 17 sites in Paris where syringe retrieval devices are located. The analysis results showed that 23% of the syringes contained 4-methylethylcathinone. The appearance of this cathinone and its growing presence in the syringes was observed between summer and winter 2012, mainly at sites where cocaine was the most previously injected drugs.

A 2011 study of Irish prisoners showed that this population reported injecting cathinones. It found that a last year prevalence of injection of mephedrone was 13% among females and 2% among males. The respective figures for methylone were 7% and 1% (Drummond, et al. 2014). Data from a 2012 needle and syringe programme survey in Ireland reported that over 6 % of the participants had used mephedrone in the past month, and of these 95 % had injected it. In addition, several in-depth qualitative studies that confirm the presence of mephedrone injection have been conducted in Dublin (e.g. Van Hout and Bingham, 2012).

In Austria a small 2010 survey among drug treatment clients in Graz (n=27) identified that just under 60 % of surveyed mephedrone users reported injecting the drug. The reported frequency of use was relatively intensive among this group, with 50 doses of the drug per week on average, and a third of respondents reporting that mephedrone was the drug causing them the most problems. Both older polydrug users and younger users without previous opioid experience were represented among these users (Austrian Reitox national focal point, 2013). At present, mephedrone appears to be declining in Austria (Austrian Reitox national focal point, 2014).

Mephedrone injection has also been reported in the United Kingdom, based on law enforcement reports (Chadd, 2013), lthough the evidence of increased mephedrone injection in the study location (South Wales) was mainly anecdotal. In addition, the national Druglink Street Drug Trends 2012 survey in the UK reported on mephedrone users who were experiencing multiple harms and making contact with drug services. These included both experienced users of other drugs switching to mephedrone, and novice users who have never injected other drugs before. Some users were mixing mephedrone with heroin, in a ‘speedball’ type of use. Mephedrone users were reportedly younger than other groups of high-risk drug users seen by drug services. In 2013, the Unlinked Anonymous Monitoring Survey of people who inject drugs in contact with services found that during the preceding year 8% of the participants had injected mephedrone (Public Health England, 2014; Health Protection Scotland, Public Health Wales, and Public Health Agency Northern Ireland, 2014).

A recent survey among Spanish harm reduction centre clients in Barcelona highlighted the injecting use of the synthetic cathinone 4-MEC among this population. In this study, 46 % of clients reported lifetime consumption of any new psychoactive substance (most often 4-MEC), mostly in combination with heroin, and half of users had injected the NPS. Analysis of urine samples also identified recent 4-MEC use in almost 20 % of the tested samples (Aranda et al., 2014).

A similar study at city level was carried out in Finland in the Helsinki area. Of a sample of 100 ‘marginalised drug users’, 54 reported using MDPV in the past year and of these 96 % had injected the drug (Tammi et al., 2011).

There is additional limited data on the use of cathinones or more generally of NPS by people who inject drugs, but where the route of administration is non-specified or unknown. For example, survey data from low-threshold programme clients in the Czech Republic in 2012, of whom 95% were injectors, found 10.5% had used a new synthetic drug in the last year. In 2013, about one third of high risk drug users in Prague – who are mostly injectors – (4,800) were estimated to have used new synthetic drugs likely containing synthetic cathinones (such as Funky and El Magico) in the last 12 months, however just few (approximately 2%) have reported synthetic cathinones as primary drug (Czech national focal point, 2015). Similarly, a 2012 survey of clients at needle and syringe programmes in Poland found that 15% of clients reported ‘new psychoactive drugs’ as their most problematic substance, while 12% had used mephedrone in the month preceding the survey (and 14% had used other NPS).

In the Swedish city of Västerås, an increase in the number of cases of stimulant-related intoxications requiring admission to the hospital emergency department fuelled further investigation of this phenomenon. This revealed that 76% of cases were related to the use of the cathinone MDPV and 95% occurred among chronic drug users who were often hepatitis C virus (HCV) positive, signalling drug injection (Lindeman et al., 2012).

Cathinones injecting among men who have sex with men (MSM)

There is increasing concern about the emergence of a new trend among some sub-groups of gay men involving the injection of illicit drugs, including cathinones and methamphetamine, in a practice known as ‘slamming’. This usually takes place at ‘chem sex’ parties (Bourne et al., 2014) where mephedrone is typically used in parallel or in combination with other drugs such as methamphetamine (London), GHB/GBL, cocaine (France) and sildenafil (‘Viagra’) to enhance sexual experiences. Parties can last from around eight hours up to three days (Spire et al., 2013) with the participants frequently engaging in risky sexual practices such as not using condoms and sharing multiple partners (Stuart, 2013). Consequently, this form of use is associated with a highly elevated risk of the spread of blood-borne and sexually transmitted diseases. In London, data from Antidote, a specialist drug clinic targeting services at the gay community, showed that 75% of clients using mephedrone were doing so solely to facilitate sex, with 80% injecting it. Of these users, 75% reported being human immunodeficiency virus (HIV) positive and 70% reported sharing needles. Similar findings were reported from a French hospital, where the majority of cases admitted to care due to synthetic cathinones use were gay men, 75% injected the drugs and 70% were HIV positive. Moreover, over half (13/20) suffered from psychiatric disorders at admission (Batisse et al., 2013). To date in Europe, this new practice has primarily been documented among restricted sub-groups of gay men mainly in London and a small, but increasing number of French cities (Lahaie et al., 2013); however, the potential exists, in this highly mobile population, for it to become more widespread.


This analysis has documented emerging evidence of new patterns of synthetic cathinone injection amongst subpopulations of drug users in Europe. There is concern about the addictive potential of these drugs and associated physical and mental health harms experienced by users (see Health consequences), and about the high-risk behaviours associated with injection of these substances. While at present there are no specific interventions targeted at synthetic cathinones users, given that, for several researched synthetic cathinones, there appear to be similar mechanisms of action, effects and harms as for amphetamines, interventions with evidence of effectiveness for these drugs may prove useful (EMCDDA, 2014). Bearing in mind the serious potential impact of new patterns of injection being identified, the close monitoring of synthetic cathinones use in Europe is clearly an important public health priority.


  • (1) Czech Republic, Spain, Slovenia, Slovakia, Poland, Portugal and the United Kingdom.
  • (2) The known minimum and maximum are 0.9% (Flemish study) and 13.8% (UK study).
  • (3) The methodology can be found in Péterfi et al., 2014.


2. Interactive: demystifying the chemistry

Loading interactive feature… please wait

Synthetic cathinones are related to the parent compound cathinone, one of the naturally occurring psychoactive substances found in the khat plant (Catha edulis Forsk). Cathinone is an analogue of amphetamine, having a ketone group on the β-carbon of its side-chain. For this reason, cathinones can be described as 'beta-keto' (βk) analogues of phenethylamines and, like most of their chemical relatives, many of them possess stimulant properties. The core molecular structure of synthetic cathinones derivatives is cathinone (2-amino-1-phenyl-1-propanone or 2-aminopropiophenone). The possible substitution patterns of the synthetic cathinones, known as 'substitutions', occur when any of the hydrogen atoms attached to the phenyl ring, the alpha-carbon of the side chain or the nitrogen atom are replaced with other substituents or functional groups. Using this interactive tool you can select different combinations of substituents and build up to 60 molecules to find out more about the synthetic cathinones that are being monitored by the EU Early Warning System.

Name R1 R2 R3 R4 R5
βk-2C-B -H -H 4-Br-2,5-(OCH3)2 -H -H
Metamfepramone -CH3 -CH3 phenyl -CH3 -H
Ethylcathinone -C2H5 -H phenyl -CH3 -H
3’,4'-Methylenedioxy-α-PPP / MDPPP pyrrolidinyl pyrrolidinyl 3,4-O2CH2 -CH3 -H
Mephedrone -CH3 -H 4-CH3 -CH3 -H
4-methylethcathinone / 4-MEC -C2H5 -H 4-CH3 -CH3 -H
Benzedrone / 4-MBC -Benzyl -H 4-CH3 -CH3 -H
3,4-Methylenedioxypyrovalerone / MDPV pyrrolidinyl pyrrolidinyl 3,4-O2CH2 -C3H7 -H
4-Ethylmethcathinone / 4-EMC -CH3 -H 4-C2H5 -CH3 -H
Methedrone / bk-PMMA -CH3 -H 4-OCH3 -CH3 -H
3',4'- Methylenedioxy-α-methylPPP /MDMPP pyrrolidinyl pyrrolidinyl 3,4-O2CH2 -CH3 -CH3
Brephedrone / 4-BMC -CH3 -H 4-Br -CH3 -H
4-BEC -C2H5 -H 4-Br -CH3 -H
4-Fluorocathinone -H -H 4-F -CH3 -H
Flephedrone / 4-FMC -CH3 -H 4-F -CH3 -H
3-Methylmethcathinone / 3-MMC -CH3 -H 3-CH3 -CH3 -H
3-fluoromethcathinone / 3-FMC -CH3 -H 3-F -CH3 -H
2,4,5-Trimethylmethcathinone / 2,4,5-TMMC -CH3 -H 2-OCH3,4-CH3,5-OCH3 -CH3 -H
2-FMC -CH3 -H 2-F -CH3 -H
Buphedrone -CH3 -H phenyl -C2H5 -H
N-ethylbuphedrone -C2H5 -H phenyl -C2H5 -H
4’-methyl-α-PPP / MPPP pyrrolidinyl pyrrolidinyl 4-CH3 -CH3 -H
1-phenyl-2-(piperidin-1-yl)butan-1-one pyrrolidinyl pyrrolidinyl phenyl -C2H5 -H
4-Methylbuphedrone / 4-Me-MABP -CH3 -H 4-CH3 -C2H5 -H
4-methylbuphedrone, N-benzyl derivative -Benzyl -H 4-CH3 -C2H5 -H
4’-Methyl-α-pyrrolidinobutyrophenone / MPBP pyrrolidinyl pyrrolidinyl 4-CH3 -C2H5 -H
3',4'-Methylenedioxy-α-pyrrolidinobutyrophenone / MDPBP pyrrolidinyl pyrrolidinyl 4-CH3 -C2H5 -H
pentedrone / β-ethyl-methcathinone -CH3 -H phenyl -C3H7 -H
4'-Methyl-α-pyrrolidinohexanophenone / MPHP pyrrolidinyl pyrrolidinyl 4-CH3 -C4H9 -H
4-Methyl-N-ethylnorpentedrone -C2H5 -H 4-CH3 -C3H7 -H
4F-α-PVP pyrrolidinyl pyrrolidinyl 4-F -C3H7 -H
α-Pyrrolidinopropiophenone / PPP pyrrolidinyl pyrrolidinyl phenyl -CH3 -H
α-Pyrrolidinobutyrophenone / α-PBP pyrrolidinyl pyrrolidinyl phenyl -C2H5 -H
α-Pyrrolidinovalerophenone / α-PVP pyrrolidinyl pyrrolidinyl phenyl -C3H7 -H
α-PEP pyrrolidinyl pyrrolidinyl phenyl -C5H11 -H
Methylone / bk-MDMA -CH3 -H 3,4-O2CH2 -CH3 -H
3,4-dimethylmethcathinone / 3,4-DMMC -CH3 -H 3,4-O2CH2 -CH3 -H
Dimethylone / bk-MDDMA -CH3 -CH3 3,4-O2CH2 -CH3 -H
Ethylone / bk-MDEA -C2H5 -H 3,4-O2CH2 -CH3 -H
2-Benzylamino-1-(3,4-methylenedioxyphenyl)propan-1-one / BMDP -Benzyl -H 3,4-O2CH2 -CH3 -H
Butylone / bk-MBDB -CH3 -H 3,4-O2CH2 -C2H5 -H
Dibutylone / bk-MMBDB -CH3 -CH3 3,4-O2CH2 -C2H5 -H
bk-PBDB -C3H7 -H 3,4-O2CH2 -C2H5 -H
2-Benzylamino-1-(3,4-methylenedioxyphenyl)butan-1-one / BMDB -Benzyl -H 3,4-O2CH2 -C2H5 -H
Pentylone -CH3 -H 3,4-O2CH2 -C3H7 -H
α-Pyrrolidinohexanophenone / α-PHP pyrrolidinyl pyrrolidinyl phenyl -C4H9 -H
4'-Methoxy-C-PPP / MOPPP pyrrolidinyl pyrrolidinyl 4-OCH3 -CH3 -H
4-MeO-alpha-PVP pyrrolidinyl pyrrolidinyl 4-OCH3 -C3H7 -H
3,4-Dimethylethcathinone / 3,4-DMEC -C2H5 -H 3-CH3,4-CH3 -CH3 -H
α-Ethylaminopentiophenone -C2H5 -H phenyl -C3H7 -H
Eutylone -C2H5 -H 3,4-O2CH2 -C2H5 -H
Hexedrone / β-propyl-methcathinone -CH3 -H phenyl -C4H9 -H
3,4-DMeO-α-PVP pyrrolidinyl pyrrolidinyl 3-OCH3,4-OCH3 -C3H7 -H
4'-chloro-α-PPP pyrrolidinyl pyrrolidinyl 4-Cl -CH3 -H
4-fluoro-N-isopropylnorpentedrone -CH(CH3)2 -H 4-F -C3H7 -H
3-methoxymethcathinone -CH3 -H 3-OCH3 -CH3 -H
βk-2C-B cathinone /sites/default/files/cathinones/bk-2C-B.png 317 306 Bk-2C-B 0 0
Metamfepramone cathinone /sites/default/files/metamfepramone.png 317 198 Metamfepramone 0 0
Ethylcathinone cathinone /sites/default/files/ethylcathinone.png 364 198 ethylcathinone 0 0
3’,4'-Methylenedioxy-α-PPP / MDPPP cathinone /sites/default/files/MDPPP.png 349 198 mdppp 0 0
Mephedrone cathinone /sites/default/files/mephedrone.png 364 198 mephedrone 0 0
4-methylethcathinone / 4-MEC cathinone /sites/default/files/4-MEC.png 411 198 4mec 0 0
Benzedrone / 4-MBC cathinone /sites/default/files/benzedrone-4-MBC.png 504 225 4mbc 0 0
3,4-Methylenedioxypyrovalerone / MDPV cathinone /sites/default/files/mdpv.png 434 263 mdpv 0 0
4-Ethylmethcathinone / 4-EMC cathinone /sites/default/files/4-EMC.png 411 198 4emcc 0 0
Methedrone / bk-PMMA cathinone /sites/default/files/methedrone.png 411 198 bkpmma 0 0
3',4'- Methylenedioxy-α-methylPPP / MDMPP cathinone /sites/default/files/MDMPP.png 439 209 mdmpp 0 0
Brephedrone / 4-BMC cathinone /sites/default/files/4-BMC.png 364 198 4bmc 0 0
4-BEC cathinone /sites/default/files/ 4bec.png 411 198 4bec 0 0
4-Fluorocathinone cathinone /sites/default/files/4-fluorocathinone.png 317 198 4fluorocathinone 0 0
Flephedrone / 4-FMC cathinone /sites/default/files/4-FMC.png 364 198 4fmc 0 0
3-Methylmethcathinone / 3-MMC cathinone /sites/default/files/3-MMC.png 317 252 3mmc 0 0
3-fluoromethcathinone / 3-FMC cathinone /sites/default/files/3-FMC.png 317 252 3fmc 0 0
2,4,5-Trimethylmethcathinone / 2,4,5-TMMC cathinone /sites/default/files/2-4-5-TMMC.png 364 252 245tmmc 0 0
2-FMC cathinone /sites/default/files/2-FMC.png 317 198 2fmc 0 0
Buphedrone cathinone /sites/default/files/buphedrone.png 317 198 buphedrone 0 0
N-ethylbuphedrone cathinone /sites/default/files/N-ethylnorbuphedrone.png 364 198 ethylbuphedrone 0 0
4’-methyl-α-PPP / MPPP cathinone /sites/default/files/4-methyl-a-PPP.png 403 209 mppp 0 0
1-phenyl-2-(piperidin-1-yl)butan-1-one cathinone /sites/default/files/1-phenyl-2-(piperidin-1-yl)butan-1-one.png 364 225 1pheynl2piperidin 0 0
4-Methylbuphedrone / 4-Me-MABP cathinone /sites/default/files/4-Me-MABP.png 364 198 4memabp 0 0
4-methylbuphedrone, N-benzyl derivative cathinone /sites/default/files/4-methylbuphedrone, N-benzyl derivative.png 504 225 4methylbuphedronenbenzyl 0 0
4’-Methyl-α-pyrrolidinobutyrophenone / MPBP cathinone /sites/default/files/MPBP.png 403 209 mpbp 0 0
3',4'-Methylenedioxy-α-pyrrolidinobutyrophenone / MDPBP cathinone /sites/default/files/3-4-methlenedioxy-a-pyrrolidinobutyrophenone.png 439 209 mdpbp 0 0
pentedrone / β-ethyl-methcathinone cathinone /sites/default/files/pentedrone.png 317 252 pentedrone 0 0
4'-Methyl-α-pyrrolidinohexanophenone / MPHP cathinone /sites/default/files/4-methyl-a-pyrrolidinohexanophenone.png 403 290 mphp 0 0
4-Methyl-N-ethylnorpentedrone cathinone /sites/default/files/4-methyl-N-ethylnorpentedrone.png 411 252 4methylnethylnorpentedrone 0 0
4F-α-PVP cathinone /sites/default/files/4F-a-PVP.png 403 263 4fapvp 0 0
α-Pyrrolidinopropiophenone / PPP cathinone /sites/default/files/a-pyrrolidinopropiophenone.png 356 209 ppp 0 0
α-Pyrrolidinobutyrophenone / α-PBP cathinone /sites/default/files/a-pyrrolidinobutyrophenone.png 356 209 apbp 0 0
α-Pyrrolidinovalerophenone / α-PVP cathinone /sites/default/files/a-pyrrolidinovaleophenone.png 356 263 apvp 0 0
α-PEP cathinone /sites/default/files/a-PEP.png 356 344 apep 0 0
Methylone / bk-MDMA cathinone /sites/default/files/methylone.png 400 198 bkmdma 0 0
3,4-dimethylmethcathinone / 3,4-DMMC cathinone /sites/default/files/3-4-dimethylmethcathinone.png 364 198 34dmmc 0 0
Dimethylone / bk-MDDMA cathinone /sites/default/files/dimethylone.png 400 198 bkmddma 0 0
Ethylone / bk-MDEA cathinone /sites/default/files/ethylone.png 447 198 bkmdea 0 0
2-Benzylamino-1-(3,4-methylenedioxyphenyl)propan-1-one / BMDP cathinone /sites/default/files/BMDP.png 540 225 bmdp 0 0
Naphyrone cathinone /sites/default/files/ — ASK AC     naphyrone 0 0
Butylone / bk-MBDB cathinone /sites/default/files/butylone.png 400 198 bkmddb 0 0
Dibutylone / bk-MMBDB cathinone /sites/default/files/dibutylone.png 447 198 bkMMBDB 0 0
bk-PBDB cathinone /sites/default/files/bk-PBDB.png 400 252 bkPBDB 0 0
2-Benzylamino-1-(3,4-methylenedioxyphenyl)butan-1-one / BMDB cathinone /sites/default/files/BMDB.png 540 225 BMDB 0 0
Pentylone cathinone /sites/default/files/pentylone.png 400 252 pentylone 0 0
1-naphyrone cathinone /sites/default/files/ ASK AC     1naphyrone 0 0
α-Pyrrolidinohexanophenone / α-PHP cathinone /sites/default/files/a-pyrrolidinohexanophenone.png 356 290 aphp 0 0
4'-Methoxy-C-PPP / MOPPP cathinone /sites/default/files/4-methoxy-a-PPP.png 449 209 moppp 0 0
4-MeO-alpha-PVP cathinone /sites/default/files/4-MeO-a-PVP.png 449 263 4-MeO-alpha-PVP 0 0
3,4-Dimethylethcathinone / 3,4-DMEC cathinone /sites/default/files/3-4-dimethylethcathinone.png 411 198 34DMEC 0 0
α-Ethylaminopentiophenone cathinone /sites/default/files/a-ethylaminopentiophenone.png 364 252 aEthylaminopentiophenone 0 0
Eutylone cathinone /sites/default/files/eutylone.png 447 198 Eutylone 0 0
Hexedrone / β-propyl-methcathinone cathinone /sites/default/files/hexedrone.png 317 279 Hexedrone 0 0
3,4-DMeO-α-PVP cathinone /sites/default/files/3-4-DMeO-a-PVP.png 449 263 34dmeoapvp 0 0
4'-chloro-α-PPP cathinone /sites/default/files/4-chloro-a-PPP.png 403 209 4chloroappp 0 0
4-fluoro-N-isopropylnorpentedrone cathinone /sites/default/files/4-fluoro-N-isopropylnorpentedrone.png 411 252 4-fluoro-N-isopropylnorpentedrone 0 0
3-methoxymethcathinone cathinone /sites/default/files/3-methoxymethcathinone.png 317 279 3-methoxymethcathinone 0 0
-H R1 /sites/default/files/H-R1.png 73 69   0 0
-CH3 R1 /sites/default/files/CH3-R1v2.png 102 92   0 0
-C2H5 R1 /sites/default/files/C2H5-R1.png 120 63   0 30
-C3H7 R1 /sites/default/files/C3H7-R1v2.png 186 126   0 0
-Benzyl R1 /sites/default/files/Benzyl-R1.png 219 160   0 -15
pyrrolidinyl R1 /sites/default/files/pyrrolidinylv4.png 123 105   -5 5
pyrrolidinyl R2 /sites/default/files/pyrrolidinyl-R2.png 1 1   0 0
-H R2 /sites/default/files/H-R2.png 73 69   0 0
-CH3 R2 /sites/default/files/CH3-R2v2.png 102 92   0 0
-H R4 /sites/default/files/H-R4.png 65 69   0 0
-CH3 R4 /sites/default/files/CH3-R4v3.png 102 92   3 -5
-C2H5 R4 /sites/default/files/C2H5-R4.png 117 119   20 -20
-C3H7 R4 /sites/default/files/C3H7-R4v2.png 141 161   15 -12
-C4H9 R4 /sites/default/files/C4H9-R4.png 167 200   25 -12
-C5H11 R4 /sites/default/files/C5H11-R4.png 200 244   30 -12
3,4-O2CH2 R3 /sites/default/files/3-4-O2CH2v2.png 212 144   -20 5
4-Br-2,5-(OCH3)2 R3 /sites/default/files/4-Br25--OCH3-2v2.png 224 306   -15 -35
4-Br R3 /sites/default/files/4-Brv2.png 181 144   -20 7
4-Cl R3 /sites/default/files/4-Clv2.png 186 144   -20 7
4-F R3 /sites/default/files/4-Fv2.png 186 139   -20 7
4-C2H5 R3 /sites/default/files/4-C2H5v2.png 239 126   -20 7
4-OCH3 R3 /sites/default/files/4-OCH3v2.png 236 140   -20 7
4-CH3 R3 /sites/default/files/4-CH3v2.png 190 133   -20 7
3-F R3 /sites/default/files/phenyl%20ring%20system.png 130 144   -20 7
3-OCH3 R3 /sites/default/files/3-OCH3v2.png 181 198   -20 7
3-CH3 R3 /sites/default/files/3-CH3v3.png 182 144   -20 7
2-F R3 /sites/default/files/3-Fv2.png 180 144   -20 7
phenyl R3 /sites/default/files/phenyl%20ring%20system.png 130 144   0 0
-H R5 /sites/default/files/H-R5.png 73 69   0 0
-CH3 R5 /sites/default/files/CH3-R5v2.png 57 71   5 -10

3. Facts and figures

  • Synthetic cathinones encompass a wide group of substances that are synthetic derivatives of cathinone, which is naturally present in the Khat (Catha edulis) plant. They include mephedrone, pentedrone, methylone, MDPV and 4-MEC. See the EMCDDA drug profile on synthetic cathinones.
  • Street names for synthetic cathinones vary by country and include Miaow Miaow, M-Cat, Msmack, Drone, Fert, Bubbles (in English-speaking countries), Kati, Pentakristály (in Hungary), and Funky, Cocolino, El Padrino and Magico (in the Czech Republic).
  • Synthetic cathinones mainly appear on the drug markets as powders and tablets.
  • Between 2005 and 2014 more than 81 synthetic cathinone derivatives were reported to the EU Early Warning System (see Interactive: demystifying the chemistry).
  • Methcathinone was first developed in the 1930s as an antidepressant. Since then it has been used illicitly in the former Soviet Union countries and Poland (4).
  • In Israel, the use of khat-extracted cathinones spread in the early 2000s. These substances were banned in 2004; further derivatives were banned in 2010.
  • Synthetic cathinones were first seized in Europe in 2005 (methylone in the Netherlands).
  • In 2010 mephedrone was submitted to control measures in the European Union.


(4)Bretteville-Jensen et al., 2013 provide an account of the history of synthetic cathinones.

4. Health consequences

Synthetic cathinones have been linked to a range of health problems for users (Miotto et al., 2013). The drugs toxicity at high doses, which is similar to that of cocaine, MDMA and amphetamine (Dargan and Wood, 2013), has resulted in emergency room presentations across Europe; deaths involving synthetic cathinones do occur (Wood and Dargan, 2012; Corkery et al., 2012).

Injecting cathinone use has been associated with a high frequency of injection for several of the substances, with European injectors of synthetic cathinones reporting a number of injection-related and other complications. These include an intense burning sensation at the injection site, with repetitive injection resulting in skin erosion, localised infections, blisters, spots, abscesses, gangrenous tissue, blood clots, permanent numbness and spasms. In addition, some problems associated with synthetic cathinone injection and the spread of infectious diseases have been highlighted. In Hungary, possible increases in HCV infection were observed in synthetic cathinone injectors and associated with high frequency of injection (for some cathinones 11.5 times a day on average, Horvath, 2013). In Romania the high frequency of injecting these drugs (6–8 times per day according to local studies), coupled with a reduction in the availability of sterile injecting equipment, are cited as factors playing a role in recent HIV outbreaks (Botescu et al., 2012).

In addition to injection-related risks, cathinones use has also been associated with risky sexual practices (Van Hout and Brennan, 2011a; Stuart, 2013; Spire et al., 2013). In addition to reports of ‘slamming’ parties in sub-populations of MSM in London and French cities, a qualitative study of mephedrone users in Ireland reported that use of the drug even in non-injecting recreational users was linked to sexual encounters involving multiple partners and a lack of condom use (Van Hout and Brennan, 2011b).

The psychological side-effects of synthetic cathinones can include a difficult ‘comedown’, depression, anxiety, panic attacks, paranoia and psychosis. Compulsive use and dependence symptoms have been reported by synthetic cathinone users. These include strong cravings, relatively rapid development of tolerance and prolonged binges, sometimes lasting for many days. The compulsive nature of use might stem from the fact that the effects of several of these drugs are in general short-lived, with a maximum of 2–4 hours at oral administration (Corkery et al., 2012; Miotto, 2013; EMCDDA, 2010). A study of psychiatric inpatient facilities in Germany (Livak et al., 2013) reported on patient admissions presenting with synthetic cathinones-related psychotic symptoms. Psychotic states following mephedrone use often persisted for several days despite the administration of neuroleptic medication. Most of these cases were polydrug users who had often used injection as a route of administration for cathinones. Hungary has also reported high levels of psychiatric comorbidity associated with cathinone use, in addition to factors such as acute psychosis, violence and decrease in treatment compliance among this patient group (Hungarian Reitox national focal point, 2013, Szily and Bitter, 2013, Rácz and Bodrogi, 2014).


  • Miotto, K., Striebel, J., Cho, A. K. and Wang, C. (2013), ‘Clinical and pharmacological aspects of bath salt use: a review of the literature and case reports’, Drug and Alcohol Dependence, 132(1), pp. 1–12.
  • Dargan, P. and Wood, D. (eds) (2013), Novel psychoactive substances: classification, pharmacology and toxicology, chapter 9, Waltham, MA, Academic Press.
  • Wood, D. M. and Dargan, P. I. (2012), ‘Mephedrone (4-methylmethcathinone): what is new in our understanding of its use and toxicity’, Progress in Neuro-Psychopharmacology and Biological Psychiatry, 39(2), pp. 227–233.
  • Corkery, J., Schifano, F. and Ghodse, A. H. (2012), ‘Mephedrone-related fatalities in the United Kingdom: contextual, clinical and practical issues’, in Gallelli, L. (ed.), Pharmacology, InTech, doi: 10.5772/32935.
  • Horvath, G. (2013) ‘Injecting of new psychoactive substances and related risks in Hungary’, Presentation at the PDU Annual Expert Meeting, 27 September.
  • Botescu, A., Abagiu, A., Mardarescu, M. and Ursan, M. (2012), HIV/AIDS among injecting drug users in Romania: report of a recent outbreak and initial response policies, European Monitoring Centre for Drugs and Drug Addiction, Lisbon, November.
  • Van Hout, M. C. and Brennan, R. (2011a), ‘Plant food for thought: a qualitative study of mephedrone use in Ireland’, Drugs: Education, Prevention and Policy, 18(5), pp. 371–381.
  • Van Hout, M. C. and Brennan, R. (2011b), ‘“Bump and grind”: an exploratory study of mephedrone users' perceptions of sexuality and sexual risk’, Drugs and Alcohol Today, 11(2), pp. 93–103.
  • EMCDDA (2010), Risk assessment report of a new psychoactive substance: 4-methylmethcathinone (mephedrone), Publications Office of the European Union, Luxembourg.
  • Livak, V., Ehemann, M., Pilz-Gerhardinger, M., et al. (2013) „Badesalz “-Psychosen–Klinische Aspekte. SUCHT-Zeitschrift für Wissenschaft und Praxis/Journal of Addiction Research and Practice, 59(1), pp. 55–60.
  • Hungarian Reitox national focal point (2013), National report 2013: Hungary, European Monitoring Centre for Drugs and Drug Addiction, Lisbon, June.
  • Szily, E., Bitter, I. (2013): Designer drugs in psychiatric practice – A review of the literature and the recent situation in Hungary, Neuropsychopharmacol Hung, 15(4): 223-231
  • Rácz. J., Bodrogi, A. (2014): Kliensutak az új pszichoaktív szerek használóinál: a re-medikalizáció kérdése. Presented: „Új szerek, új (kliens) utak” konferencia, Budapest, 2014. március 27-28. [accessed: 28.10.2014]

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