This rapid communication provides an update on drug related hospital emergency presentations in Europe with a specific focus on the latest results for acute drug toxicity presentations to the European Drug Emergencies Network (Euro-DEN). This report is primarily based on presentations and discussions at a two-day meeting of the Euro-DEN Plus network in Lisbon on 7 and 8 April 2016. The meeting provided a platform for the presentation of new analyses from the Euro-DEN dataset, and further development and analyses of the Euro-DEN project were also discussed. Data presented here relate to analysis of acute drug toxicity presentations to the 16 original sentinel centres in the Euro-DEN network for the first two years of data collection (October 2013 to September 2015). This review also includes highlights from the new findings discussed during the meeting and consideration of the further development of the work of the Euro-DEN network and the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) in this field.