Information on drug-related emergencies in Spain originates from the National Plan on Drugs, which monitors hospital emergencies directly caused by non-medical use of psychoactive substances among 15- to 54-year-olds. In 2016, a total of 4 565 emergency episodes related to drug use were notified, the lowest level reported in the past 12 years. Cocaine was the substance most frequently reported as the cause of the emergency episodes, followed by cannabis. The proportion of heroin-related emergencies has decreased by a factor of 4 since 2000. Amphetamines and MDMA/ecstasy were less common causes of drug-related emergencies in Spain in 2016.